Okay this was too cool to keep to myself. This photo was snapped by the space shuttle as it passed by the International Space Station a few years ago. Rochester just happened to be in the background. Lake Erie and Buffalo are on the left side of the image, while Lake Ontario and Rochester are on the right. Holy smokes, I can see my house from here!
Incidentally, this SkyWatch 2.0 tool is supposed to tell you when the Space Station can be seen passing over any given location. But I don’t think I’m smart enough to know how to use it.